DNA Damage, Neurodegeneration, and Synaptic Plasticity

DNA Damage, Neurodegeneration, and Synaptic Plasticity

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy 2Instituto de Neurociencias, CSIC-UMH, Avenida Ramón y Cajal s/n, 03550 Sant Joan d’Alacant, Spain 3Institute of Applied Physiology, Ulm University, 89081 Ulm, Germany 4Institute of Anatomy and Medical Cell Biology, Heidelberg University, 69120 Heidelberg, Germany 5Klinikum Rech...

Nucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration

Nucleotide balance is critically important not only in replicating cells but also in quiescent cells. This is especially true in the nervous system, where there is a high demand for adenosine triphosphate (ATP) produced from mitochondria. Mitochondria are particularly prone to oxidative stress-associated DNA damage because nucleotide imbalance can lead to mitochondrial depletion due to low repl...

DNA damage and neurodegeneration: the unusual suspect

DNA Damage and Its Links to Neurodegeneration

The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the con...

synaptic neuronal plasticity

context the current study aimed to review research articles concerning cortical representational plasticity following the manipulations of inputs. evidence acquisition this review article compromised previous studies in pubmed, google scholar and scientific information databases according to the keywords since 1988. results ca1 neurons depolarization paired with ca3 presynaptic input result in ...